Job Details

Director, Project Management – IEP & HEOR

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The company's R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As a key leader within the Medical Excellence function, the Director, Project Management Integrated Evidence Planning (IEP) & Health Economics and Outcomes Research (HEOR) will lead cross-functional planning, execution, and governance of integrated evidence generation activities. This role will ensure seamless coordination across the entire company to deliver high-impact evidence that drives clinical adoption, patient access, and differentiation of our pipeline assets.

This is a highly collaborative and visible position requiring strategic thinking, operational excellence, and expertise in medical evidence planning—including real-world evidence (RWE), HEOR, and data generation initiatives aligned with launch strategies and lifecycle management.

Key responsibilities include:

• Strategic Program Leadership
  • Lead program management for Integrated Evidence Plans (IEP), ensuring alignment across clinical, medical, and market access functions.
  • Oversee project planning for HEOR and RWE initiatives to support product value proposition, access, and payer engagement strategies.
  • Serve as program lead for evidence generation planning in preparation for key milestones such as NDA submissions, HTA reviews, and global product launches.
• Cross-Functional Coordination
  • Facilitate collaboration between Global Medical Affairs, Clinical Development, Biostatistics, Market Access, Regulatory, and Commercial on data generation priorities and execution.
  • Drive governance of the Integrated Evidence Working Group (IEWG) and ensure transparent communication of goals, timelines, and deliverables.
  • Maintain regular check-ins with Medical Affairs and key groups to determine IEPs need to be updated.
• Operational Execution & Oversight
  • Build and manage cross-functional project plans, dashboards, and timelines to monitor progress and mitigate risks across IEP and HEOR initiatives.
  • Support internal review, approval, and documentation of evidence generation activities in alignment with compliance and SOPs.
  • Maintain calendar of IEP activities.
• Process Excellence & Infrastructure
  • Champion process improvement and operational efficiency across IEP and HEOR planning cycles.
  • Implement tools (e.g., Veeva Medical, Smartsheet) and frameworks to optimize planning, documentation, and tracking of evidence generation deliverables.
  • Help to facilitate broad IEP development and implementation.
• Stakeholder Engagement & Communication
  • Coordinate with external stakeholders including research collaborators, data vendors, and HEOR partners to ensure timely and high-quality execution.
  • Drive preparation and delivery of cross-functional updates, dashboards, and communication materials for senior leadership and governance committees.
  • Work across Medical Affairs and RWE/HEOR leadership to ensure engagement and alignment of all evidence generation activities.
  • Provide guidance and oversight to junior project management staff and contractors.
  • Oversee vendor performance and budget adherence for outsourced HEOR, RWE, or medical data generation services.

Required Skills, Experience and Education:

• Bachelor's degree required; advanced degree (MS, MPH, PharmD, PhD, MBA) or PMP certification strongly preferred.
• 15+ years of experience in biotechnology or pharmaceutical industry (with BS), 13+ years (with MS) or 11+ years (with PharmD/PhD), including 8+ years of direct project/program management in Medical Affairs or Evidence Generation.
• Deep knowledge of HEOR, RWE, and medical affairs data generation practices and compliance frameworks.
• Experience supporting integrated evidence plans, HTA submissions, and cross-functional alignment across medical, access, and commercial.
• Proven ability to lead matrix teams and influence across levels and disciplines.
• Strong project governance skills and fluency in PM tools and platforms (e.g., Veeva, Smartsheet, MS Project).
• Experience in oncology or precision medicine is highly preferred.
• Excellent communication, organization, and presentation skills.

Preferred Skills:

• Previous experience managing launch-focused IEPs in oncology.
• Familiarity with global payer evidence needs and HEOR methodologies.
• Demonstrated success implementing evidence governance models and working groups.

Compensation and Employment Details:

The base salary range for this full-time position is $204,000 to $255,000 for candidates working onsite at our headquarters in Redwood City, CA. The range displayed on each job posting is intended to be the salary for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our salary ranges are determined by role, level, and location. Individual pay is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base salary is one part of the overall total rewards program at Revolution Medicines, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

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